The estimation of linkage with incomplete penetrance
نویسندگان
چکیده
منابع مشابه
Incomplete penetrance of MHC
We propose an approach to understanding incomplete penetrance of disease susceptibility genes as a method of studying the underlying mechanisms of polygenic diseases. Incomplete penetrance is the failure of genetically susceptible individuals to exhibit a trait. We define as baseline penetrance that which occurs in genetically identical (monozygotic) twins of an index subject with a major histo...
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HE genetics of petal color and venation in the papilionate flower of the pigeon pea (Cajanus mian (L.) Millsp.) has been reported by DAVE (1934) and MENEZES (1 956), who postulated four or five independent loci to govern these characters. In the present study of six different intervarietal crosses, however, evidence was obtained for a different and relatively complex genetic basis involving lin...
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Cell colonization during embryonic development involves cells migrating and proliferating over growing tissues. Unsuccessful colonization, resulting from genetic causes, can result in various birth defects. However not all individuals with the same mutation show the disease. This is termed incomplete penetrance, and it even extends to discordancy in monozygotic (identical) twins. A one-dimensio...
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Hereditary hearing loss (HHL) comprises half of the congenital deafness which arises from genetic mutations. Mutations in the TJP2 gene, encoding tight junction protein 2, are one of the gene alterations in HHL resulting in an autosomal dominant nonsyndromic form of the disease. An 11-year-old male patient with clinically approved congenital hearing loss was referred to our laboratory....
متن کاملdeterminant of the hankel matrix with binomial entries
abstract in this thesis at first we comput the determinant of hankel matrix with enteries a_k (x)=?_(m=0)^k??((2k+2-m)¦(k-m)) x^m ? by using a new operator, ? and by writing and solving differential equation of order two at points x=2 and x=-2 . also we show that this determinant under k-binomial transformation is invariant.
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ژورنال
عنوان ژورنال: Heredity
سال: 1952
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.1952.9